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VA COVID-19 Observational Research Collaboratory (CORC)

VA COVID-19 Observational Research Collaboratory (CORC)


To improve Veteran’s health by conducting and supporting rigorous research to understand the long-term effects of SARS-CoV-2 infection while fostering research collaborations within and outside of the Department of Veterans Affairs.

Publication Spotlight

Admon AJ, Bohnert ASB, Cooke CR, Taylor SP. Beyond confounding - Identifying selection bias in observational pulmonary and critical care research. Annals ATS, in press.

COVID-19 Vaccination Effectiveness Against Infection or Death in a National U.S. Health Care System (December 21, 2021)

Study Shows Changes in the Association between Race and Urban Residence with COVID-19 Outcomes among Veterans (November 2021)


Coordinating Center (CC)

The 3 pillars of the CC are a Data Core, Methods Core, and Partnerships Core, which will work together to carry out the following aims:

  • CC-Aim 1: Develop a data infrastructure to support dynamic analytic datasets of SARS-CoV-2 infected and uninfected comparator cohorts that will facilitate research on a broad range of VHA health record-based outcomes
  • CC-Aim 2: Generate and disseminate documentation of matched comparators, exposures, outcomes, and covariates
  • CC-Aim 3: Provide methodologic guidance and support to VA investigators and operational partners
  • CC-Aim 4: Understand the medical and non-medical effects of SARS-CoV-2 by comparing clinical, economic, and patient- reported outcomes between SARS-CoV-2 infected and uninfected VHA patients
  • CC-Aim 5: Describe incidence and predictors of key long-term adverse outcomes and manifestations of SARS-CoV-2 infection

Long-Term Outcome Study (LTO)

The LTO will be responsible for carrying out a rigorous mixed methods study of the long-term effects of SARS-CoV-2 infection on Veterans, with support from the CC. By triangulating a range of data sources, the LTO will:

  • LTO-Aim 1: Compare VHA patients infected and uninfected with SARS-CoV-2 on outcomes that can be measured in electronic health records and claims datasets, such as mortality, hospital readmissions, new and exacerbated conditions, and new mental health conditions
  • LTO-Aim 2: Compare VHA patients infected and uninfected by SARS-CoV-2 on veteran-reported outcomes, including as self-reported symptoms, disability, informal caregiving receipt, and financial impacts
  • LTO-Aim 3: Elicit Veteran experiences of recovery after SARS-CoV-2 infection through semi-structured interviews
  • LTO-Aim 4: Estimate current and future health system needs to address long-term effects of SARS-CoV-2

For more information on VA research projects related to COVID-19:

Participating in Research

Anyone over the age of 18, including Veterans, their friends and family of Veterans, and VA staff can participate in VA national COVID-19 research efforts by registering at

Collaborating VA Medical Centers


Additional Locations

  • Population Health, Palo Alto VA

Data Resources/Collaborators


The CORC is supported by the Department of Veterans Affairs. Primary funding comes from:

Additional support comes from the following sources:

Questions about the R&D website? Email the Web Team.

Any health information on this website is strictly for informational purposes and is not intended as medical advice. It should not be used to diagnose or treat any condition.