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VA Central Institutional Review Board (IRB)

If you are new to IRBNet, please register for a user account at Registration instructions can be found here. Additional training resources are also available on the VAIRRS SharePoint portal.

For questions, please contact us at

Additional information can be found on VAIRRS.

VA Central IRB Updates

Forms Update
The VA Central IRB has removed Investigator signature lines from ALL of our submission forms to better align with VAIRRS IRB submissions forms. All updated forms can be found in our VA Central IRB Forms and Templates Library. Please ensure that you begin using these new forms for your next Central IRB submission.

IRBNet Package Signature
The VA Central IRB requires that the Investigator (or designee) sign the package in IRBNet for New Project submissions only. All other submission types do not require an Investigator (or designee) signature but can be signed by other study team members. Please note that this may differ from your local research administration requirements.

Please ensure to download CIRB submission forms from the IRBNet Forms & Templates Library each time you are compiling a package to ensure that you are using the most current and up to date forms.

If you have any questions concerning VA CIRB processes, please check information on the VA Central IRB Submissions page.  If you cannot find an answer, e-mail the VA Central IRB general mailbox at or call the VA Central IRB Toll Free Number at 1-877-254-3130.

Purpose: The purpose of the VA Central IRB is two-fold. First and foremost its purpose is to enhance the quality of human research protection in multi-site human research projects by performing appropriate ethical and scientific review while ensuring local issues are addressed. In this role, the VA Central IRB also provides the single IRB oversight required for multi-site studies by the 2018 Common Rule. The second is to enhance the efficiency of these reviews across participating sites.

VA Facilities: Each VA facility that plans to use the VA Central IRB must add the VA Central IRB to its Federalwide Assurance (FWA) and sign a Memorandum of Understanding (MOU) with the VHA Central Office (VHACO) Human Research Protection Program (HRPP). The MOU clearly delineates the respective roles and responsibilities of each entity. The local VA has ultimate and immediate responsibility for its HRPP. Instructions for adding the VA Central IRB as an IRB of Record are also included on this website, as are the VA Central IRB SOPs and forms.

In addition, any affiliated Nonprofit Research and Education Corporation (NPC) for a VA site that has entered into an MOU with the VHACO HRPP, should also sign the MOU and update its FWA to add the VA Central IRB as an IRB of Record.

VA Investigators: Investigators whose studies are being funded by VA ORD should consult the ORD funding service to determine whether their study should be submitted to the VA Central IRB.  Investigators who are new to the VA CIRB and whose studies will be reviewed by the VA Central IRB should contact the VA Central IRB mailbox (, as far in advance of the planned submission as possible to request an introductory meeting and pre-submission consultation in order to submit the most likely application for approval. Information concerning the operations of the VA Central IRB can also be found on this website under the Important Links box on the right-hand side of this page.

Questions about the R&D website? Email the Web Team

Any health information on this website is strictly for informational purposes and is not intended as medical advice. It should not be used to diagnose or treat any condition.