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Funded Project Details - FY2021




Project Number:

I01BX003335-05A1
Title: Mechanisms underlying dampened ischemic tolerance in type 2 diabetes
Principal Investigator:

Jialing Liu

Location: San Francisco, CA
Congressional District Code: 12
Research Service: Biomedical Laboratory R&D
Project Period: April 2021 - March 2025
FY 2021 Funding Amount: $128,400
Total Award Amount
(all years):
$710,000
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Tolerance to cerebral ischemia can be induced by exposure to brief ischemia or pharmacological agents including the Toll-like receptor (TLR) agonists, a phenomenon known as the ischemic preconditioning (IPC). Established evidence suggests that innate immune pathways such as TLRs and type 1 interferon (IFN) signaling are involved in IPC-mediated neuroprotection. Although it is well known that tolerance to ischemia or the effect of IPC declines with age and pathological conditions including metabo...



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