The role of IL17A and keratinocyte stem cells in human psoriasis.
San Francisco, CA
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Clinical Science R&D
April 2021 -
FY 2021 Funding Amount:
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View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt:
BACKGROUND: Psoriasis is a benign inflammatory immunological disorder characterized by hyperproliferation of the epidermis. The role of stem cell (SC) divisional behavior in the hyperproliferation of psoriasis has not been addressed previously. PRELIMINARY DATA: As part of our last completed Merit Review we provided evidence to show that while oncogenic hyperproliferation is associated with symmetric SC divisions (producing increased numbers of SCs), benign hyperproliferation is associated with...