Office of Research & Development |
  |
Talk to the Veterans Crisis Line now
An official website of the United States government
Project Number: | I01BX003863-05 |
| Title: | Targeting Innate Immunity as A Therapeutic Intervention for Parkinsons Disease |
| Principal Investigator: | John Beckham |
| Location: | Denver, CO |
| Congressional District Code: | 6 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | July 2021 - June 2025 |
| FY 2021 Funding Amount: | $89,200 |
| Total Award Amount (all years): |
$710,000 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: This proposal is a renewal of our current VA Merit award and is focused on understanding the interactions between innate immune responses and Parkinson’s Disease (PD) pathogenesis. We previously discovered that the neuronal protein, alpha-synuclein (α-syn), protects the brain from viral infections. With our current VA Merit support, we extended these findings to discover that α-syn expression in neurons is required for expression of neuronal interferon stimulated gene (ISG) expression independen... |