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Funded Project Details - FY2021

Project Number:

Title: Recognition of Mtb-Infected Cells by Non-Classically Restricted CD8 T Cells
Principal Investigator:

David M. Lewinsohn

Location: Portland, OR
Congressional District Code: 3
Research Service: Biomedical Laboratory R&D
Project Period: January 2021 - December 2024
FY 2021 Funding Amount: $166,916
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Project Summary Tuberculosis (TB) is a leading cause of infectious disease mortality worldwide, accounting for 10.4 million new cases and 1.3 million deaths annually. An understanding of the immune response to Mtb is of central importance in the development of improved vaccines. In this regard our laboratory, under the auspices of the VA Merit Program, has defined Mucosal Associated Invariant T (MAIT) cells as a class of cells that are restricted by the highly conserved MR1 molecule, recognize M...

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