Stimulation of Native Joint-resident Precursors for Cartilage Repair in Osteoarthritis
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Biomedical Laboratory R&D
October 2020 -
FY 2021 Funding Amount:
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View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt:
Osteoarthritis (OA), in particular, post-traumatic osteoarthritis (PTOA) is highly prevalent in U.S. military service members and veterans due to the impact of joint trauma and overuse injury. Its socioeconomic impact is substantial, estimated to approach $60 billion per year, and no disease-modifying treatments exist. Current understanding is that PTOA is caused by maladaptive repair responses including activation of the pro- inflammatory pathways of innate immunity that in turn result in pain,...