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Project Number: | I01BX004845-01A1 |
| Title: | Genome engineering of stem cells for kidney regeneration |
| Principal Investigator: | Lauren E Woodard |
| Location: | Nashville, TN |
| Congressional District Code: | 5 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | April 2020 - March 2024 |
| FY 2021 Funding Amount: | $339,269 |
| Total Award Amount (all years): |
$1,388,813 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: We propose to develop a regenerative gene and cell therapy treatment for acute kidney injury and/or chronic kidney disease. These studies are based on recent advances in isolation of adult stem cells from the urine. Urine-derived stem cells have several remarkable properties: they are easy to obtain, propagate for many passages, are multipotent, and home to sites of injury. We propose to genome modify urine-derived stem cells and track their homing in three mouse models of kidney injury (ischemi... |