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Funded Project Details - FY2021

Project Number:

Title: Precancer Niche Formation in the Fallopian Tube
Principal Investigator:

Sandra Orsulic

Location: West Los Angeles, CA
Congressional District Code: 28
Research Service: Biomedical Laboratory R&D
Project Period: July 2020 - June 2024
FY 2021 Funding Amount: $275,645
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Background: Ovarian cancer is the most fatal gynecologic cancer. While curative treatments exist for early- stage cancers, there is a lack of specific biomarkers for detecting preneoplastic lesions, which usually occur in the fallopian tube epithelia (FTE). Normal FTE consists of small clusters of secretory and ciliated cells intermixed in an approximately 1:1 ratio. Although the mechanism of FTE transformation is not fully understood, it is believed that hormones and growth factors in the folli...

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