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Project Number: | I01BX001370-05A2 |
| Title: | Convergence of Endothelin-1 and Androgen Signaling in Prostate Cancer Bone Metastasis |
| Principal Investigator: | Gregory A Clines |
| Location: | Ann Arbor, MI |
| Congressional District Code: | 12 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | April 2020 - March 2024 |
| FY 2021 Funding Amount: | $156,800 |
| Total Award Amount (all years): |
$710,000 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Prostate cancer is the most common deadly cancer of men. Bone metastasis is a painful complication of advanced prostate cancer associated with significant morbidity. Endothelin-1 (ET-1) is a prostate cancer- secreted factor that activates the osteoblast endothelin A receptor (ETAR) causing osteoblast proliferation and pathologic new bone formation. In turn, osteoblasts send chemotactic and growth cues back to the prostate cancer cells. Preliminary data have unexpectedly demonstrated that ablatio... |