New Epigenetic Targets in Ovarian Cancer Stem Cells
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Biomedical Laboratory R&D
October 2019 -
FY 2021 Funding Amount:
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View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt:
Abstract Development of resistance to chemotherapy was linked to persistence of cancer stem cells (CSCs). CSCs are characterized by the ability to self-renew, grow as spheres, differentiate and generate tumors in immunodeficient mice. They are resistant to traditional forms of treatment, including chemo and radio-therapy. Building on our previous work showing that ovarian CSCs residual after treatment with platinum display increased DNA methylation, we hypothesized that other epigenetic modifica...