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Funded Project Details - FY2021




Project Number:

IK2BX004523-01A1
Title: Reprogramming T Cells in Rheumatoid Arthritis
Principal Investigator:

Ruth J Napier

Location: Portland, OR
Congressional District Code: 3
Research Service: Biomedical Laboratory R&D
Project Period: July 2019 - June 2024
FY 2021 Funding Amount: $169,142
Total Award Amount
(all years):
$1,101,492
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Rheumatoid arthritis (RA) is a chronic disease involving painful destruction of the joints and eventual loss of function. Although its etiology remains unknown, genetic and experimental data strongly suggest deleterious CD4+ T cell responses drive the pathogenesis of RA. Current treatment strategies aimed at modifying late- stage consequences of inflammation do not correct underlying T cell defects and are therefore not curative. Thus, a better understanding of intrinsic regulatory factors of ar...



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