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Funded Project Details - FY2021




Project Number:

I01BX002547-05A1
Title: Dynamic Chemical Regulation of Voltage-gated Sodium Channels
Principal Investigator:

Stephen M Smith

Location: Portland, OR
Congressional District Code: 3
Research Service: Biomedical Laboratory R&D
Project Period: July 2019 - June 2023
FY 2021 Funding Amount: $156,715
Total Award Amount
(all years):
$705,398
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Voltage-gated sodium channels (VGSCs) are essential for action potential generation. Regulation of voltage- gated ion channel function is an important pathway by which neuronal signaling and brain function is regulated, and G-protein coupled receptors (GPCRs) form a major element of the endogenous transduction mechanisms by which this occurs. However, unlike other ion channels, VGSCs have been believed to be relatively insensitive to modulation by GPCR signaling. We have recently identified a pa...



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