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Project Number: | I01BX002547-05A1 |
| Title: | Dynamic Chemical Regulation of Voltage-gated Sodium Channels |
| Principal Investigator: | Stephen M Smith |
| Location: | Portland, OR |
| Congressional District Code: | 3 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | July 2019 - June 2023 |
| FY 2023 Funding Amount: | $131,915 |
| Total Award Amount (all years): |
$705,398 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Voltage-gated sodium channels (VGSCs) are essential for action potential generation. Regulation of voltage- gated ion channel function is an important pathway by which neuronal signaling and brain function is regulated, and G-protein coupled receptors (GPCRs) form a major element of the endogenous transduction mechanisms by which this occurs. However, unlike other ion channels, VGSCs have been believed to be relatively insensitive to modulation by GPCR signaling. We have recently identified a pa... |