Talk to the Veterans Crisis Line now
U.S. flag
An official website of the United States government

Office of Research & Development

print icon sign up for VA Research updates

Funded Project Details - FY2023

Project Number:

Title: Dynamic Chemical Regulation of Voltage-gated Sodium Channels
Principal Investigator:

Stephen M Smith

Location: Portland, OR
Congressional District Code: 3
Research Service: Biomedical Laboratory R&D
Project Period: July 2019 - June 2023
FY 2023 Funding Amount: $131,915
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Voltage-gated sodium channels (VGSCs) are essential for action potential generation. Regulation of voltage- gated ion channel function is an important pathway by which neuronal signaling and brain function is regulated, and G-protein coupled receptors (GPCRs) form a major element of the endogenous transduction mechanisms by which this occurs. However, unlike other ion channels, VGSCs have been believed to be relatively insensitive to modulation by GPCR signaling. We have recently identified a pa...

Questions about the R&D website? Email the Web Team

Any health information on this website is strictly for informational purposes and is not intended as medical advice. It should not be used to diagnose or treat any condition.