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Project Number: | I01BX004372-01A2 |
| Title: | Regulation of Detrusor Overactivity by Cellular Stress in Bladder Ischemia |
| Principal Investigator: | Kazem M. Azadzoi |
| Location: | Boston, MA |
| Congressional District Code: | 7 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | July 2019 - June 2023 |
| FY 2021 Funding Amount: | $362,790 |
| Total Award Amount (all years): |
$1,679,575 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: The overall goal of this renewal research proposal is to determine the role of ischemia in the development of detrusor overactivity in the non-obstructed bladder. Another goal is to examine the efficacy of targeting cellular stress response pathways to prevent or reverse bladder dysfunction. Lower urinary tract symptoms (LUTS) are bothersome constellation of voiding symptoms with significant impact on quality of life. The prevalence of bladder dysfunction and LUTS among Veterans is almost five f... |