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Funded Project Details - FY2021

Project Number:

Title: Molecular Mechanisms of a Male-Specific Positive Feedback Loop in Liver Cancer
Principal Investigator:

Yun-Fai Chris Lau

Location: San Francisco, CA
Congressional District Code: 12
Research Service: Biomedical Laboratory R&D
Project Period: July 2019 - June 2024
FY 2021 Funding Amount: $156,800
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Hepatocellular carcinoma (HCC) is a deadly cancer that affects more Veterans than the general American population. Risk factors include hepatitis virus infection, obesity, aging, alcohol/drug abuses, toxic exposure, and genetic/epigenetic predisposition, which collectively promote genetic mutations, cell proliferation and signaling pathway dysfunctions, leading to cancer. Significantly, men are affected 3 to 6 times higher than women in HCC. The male predominance in HCC has been a long-standing...

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