Office of Research & Development |
  |
Talk to the Veterans Crisis Line now
An official website of the United States government
Project Number: | I01BX004446-01A1 |
| Title: | Molecular Mechanisms of a Male-Specific Positive Feedback Loop in Liver Cancer |
| Principal Investigator: | Yun-Fai Chris Lau |
| Location: | San Francisco, CA |
| Congressional District Code: | 12 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | July 2019 - June 2024 |
| FY 2021 Funding Amount: | $156,800 |
| Total Award Amount (all years): |
$698,050 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Hepatocellular carcinoma (HCC) is a deadly cancer that affects more Veterans than the general American population. Risk factors include hepatitis virus infection, obesity, aging, alcohol/drug abuses, toxic exposure, and genetic/epigenetic predisposition, which collectively promote genetic mutations, cell proliferation and signaling pathway dysfunctions, leading to cancer. Significantly, men are affected 3 to 6 times higher than women in HCC. The male predominance in HCC has been a long-standing... |