Optimal Dosing Regimen to Recover from Muscle Atrophy
Richard L. Lieber
Congressional District Code:
July 2019 -
FY 2021 Funding Amount:
Total Award Amount (all years):
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt:
Skeletal muscle atrophy in the Veteran population is extremely common and may arise due to poor nutrition, denervation, head injury, limb trauma, cancer, ageing, and disuse. Atrophy results from mechanical unloading of muscle over a prolonged period, resulting in reduced muscle mass, area, and strength (without a reduction of myofibers) and can be disabling. For almost a century it has been known that transient exposure to glucocorticoids (GC) enhances physical performance and increases enduranc...