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Funded Project Details - FY2021

Project Number:

Title: NAPS: Niacin for Parkinson's Disease
Principal Investigator:

Chandramohan Wakade

Location: Augusta, GA
Congressional District Code: 10
Research Service: Clinical Science R&D
Project Period: April 2019 - March 2024
FY 2021 Funding Amount: $416,645
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


PROJECT SUMMARY/ABSTRACT We are the first group to demonstrate chronic vitamin B3 (niacin and niacinamide) deficiency in individuals with Parkinson's disease (PD). Niacin and niacinamide are the source of NAD which supplies energy and DNA repair to every cell in the body. PD patients frequently report symptoms which we believe are related to the vitamin deficiency, including daytime fatigue, sleep dysfunction and low-level mood. In addition, niacin but not niacinamide acts on GPR109A, an anti-in...

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