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Funded Project Details - FY2021

Project Number:

Title: Molecular mechanisms of glucocorticoid-induced bone loss
Principal Investigator:

Charles A O'Brien

Location: Little Rock, AR
Congressional District Code: 2
Research Service: Biomedical Laboratory R&D
Project Period: January 2019 - December 2022
FY 2021 Funding Amount: $247,113
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Glucocorticoid administration is frequently used to suppress inflammation and treat a variety of conditions in the VA patient population. One of the most significant side effects of this therapy is bone loss and increased risk of fracture. We have developed a murine model of glucocorticoid-induced bone loss that mimics many of the structural and histological changes observed in humans. In addition, we have used mice with genetic deletion of the glucocorticoid receptor in specific cell types to i...

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