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Funded Project Details - FY2021




Project Number:

I01BX001721-05A2
Title: Thiamine deficiency and alcohol-induced neurodegeneration
Principal Investigator:

Jia Luo

Location: Iowa City, IA
Congressional District Code: 6
Research Service: Biomedical Laboratory R&D
Project Period: January 2019 - December 2022
FY 2021 Funding Amount: $364,282
Total Award Amount
(all years):
$1,286,105
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Alcohol abuse causes many long-lasting health consequences; one of which is impaired cognitive functioning known as alcohol-associated dementia (AAD). AAD is caused by the morphological, neurophysiological and biochemical changes in the brain. The most devastating feature of brain damage following chronic alcohol abuse is neurodegeneration. Alcohol abuse is frequently associated with the deficiency of thiamine (vitamin B1). Besides alcohol exposure, other factors, such as genetic background, agi...



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