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Funded Project Details - FY2021




Project Number:

I01BX003656-01A2
Title: Study the role of oxysterol sulfates in NAFLD development
Principal Investigator:

Shunlin Ren

Location: Richmond, VA
Congressional District Code: 3
Research Service: Biomedical Laboratory R&D
Project Period: January 2019 - December 2022
FY 2021 Funding Amount: $261,059
Total Award Amount
(all years):
$1,377,017
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Project Summary The liver plays a pivotal role in the maintenance of lipid homeostasis. Accumulation of lipids in the liver with no alcoholic consumption leads to nonalcoholic fatty liver diseases (NAFLD). NAFLD spectrum ranges from a simple nonalcoholic fatty liver (steatosis) to steatohepatitis (NASH) and cirrhosis. Insulin resistant metabolic disorder and subsequent inflammation are the major pathogenesis for development of the diseases, but the details of the mechanisms are not fully unders...



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