Study the role of oxysterol sulfates in NAFLD development
Congressional District Code:
Biomedical Laboratory R&D
January 2019 -
FY 2021 Funding Amount:
Total Award Amount (all years):
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt:
Project Summary The liver plays a pivotal role in the maintenance of lipid homeostasis. Accumulation of lipids in the liver with no alcoholic consumption leads to nonalcoholic fatty liver diseases (NAFLD). NAFLD spectrum ranges from a simple nonalcoholic fatty liver (steatosis) to steatohepatitis (NASH) and cirrhosis. Insulin resistant metabolic disorder and subsequent inflammation are the major pathogenesis for development of the diseases, but the details of the mechanisms are not fully unders...