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Project Number: | I01BX000134-09A1 |
| Title: | Role of mLST8 in mTORC2-dependent lung cancer that are refractory to targeted therapies |
| Principal Investigator: | Jin Chen |
| Location: | Nashville, TN |
| Congressional District Code: | 5 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | April 2018 - March 2022 |
| FY 2021 Funding Amount: | $156,800 |
| Total Award Amount (all years): |
$777,500 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Project Summary/Abstract Lung cancer is the leading cause of cancer-related deaths in the US and disproportionally affects Veterans. Lung cancer subtypes that are currently refractory to targeted therapies include tumors carrying activated K-Ras or drug-resistant EGFR mutations, as well as tumors whose genetic alterations are “unknown”. Among the “unknown” category, Rictor (a unique component of mTORC2) amplification was recently identified as a driver genetic alteration in 11-13% of non-small c... |