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Project Number: | I01BX004044-01A1 |
| Title: | Investigating calcineurin regulation of pathological TDP-43 phosphorylation in ALS |
| Principal Investigator: | Nicole F Liachko |
| Location: | Seattle, WA |
| Congressional District Code: | 9 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | October 2018 - September 2022 |
| FY 2021 Funding Amount: | $293,119 |
| Total Award Amount (all years): |
$1,441,078 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Amyotrophic lateral sclerosis (ALS) is a severe progressive neurodegenerative disease characterized by degeneration of motor neurons in the brain and spinal cord, resulting in neurogenic muscle wasting, paralysis, and death. Nearly 95% of ALS cases have pathology featuring phosphorylated inclusions of the TDP-43 protein in neurons and glial cells. Furthermore, mutations in the gene coding for TDP-43 have been shown to cause some cases of ALS, indicating normal TDP-43 is critical for neuronal hea... |