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Project Number: | I01CX001038-05 |
| Title: | The neuropathology of mild traumatic brain injury in Alzheimer disease |
| Principal Investigator: | Thor D Stein |
| Location: | Bedford, MA |
| Congressional District Code: | 6 |
| Research Service: | Clinical Science R&D |
| Project Period: | October 2018 - September 2022 |
| FY 2021 Funding Amount: | $164,978 |
| Total Award Amount (all years): |
$843,264 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Repetitive head impacts (RHI) lead to severe cognitive and behavioral symptoms and the progressive neurodegeneration of chronic traumatic encephalopathy (CTE). Trauma is also a known risk factor for Alzheimer disease (AD) and we hypothesize that a prolonged period of RHI can play a causative role in the development of AD as well as CTE. Currently, there are no disease modifying treatments for CTE or AD, and diagnosis of CTE can only be made at autopsy. Furthermore, little is known about the gene... |