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Project Number: | I01CX001530-01A2 |
| Title: | The Role of Microbial Antigen-Specific T Cells in Crohn's disease |
| Principal Investigator: | Peter J Mannon |
| Location: | Omaha, NE |
| Congressional District Code: | 7 |
| Research Service: | Clinical Science R&D |
| Project Period: | July 2018 - September 2022 |
| FY 2021 Funding Amount: | $182,933 |
| Total Award Amount (all years): |
$706,250 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Microbial-antigen reactive T cells are the primary effectors of inflammatory damage in animal models of Crohn's disease, causing T cell-mediated colitis only in the presence of gut microbiota. By focusing on a proposed similar key role for T cells in Crohn's inflammation, we hypothesize that anti-flagellin antibodies that are highly shared by Crohn's patients, and characterize an aberrant B cell response, are potential markers for the presence T cell clonotypes that are reactive to the same gut... |