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Funded Project Details - FY2021

Project Number:

Title: The Role of Microbial Antigen-Specific T Cells in Crohn's disease
Principal Investigator:

Peter J Mannon

Location: Omaha, NE
Congressional District Code: 7
Research Service: Clinical Science R&D
Project Period: July 2018 - September 2022
FY 2021 Funding Amount: $182,933
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Microbial-antigen reactive T cells are the primary effectors of inflammatory damage in animal models of Crohn's disease, causing T cell-mediated colitis only in the presence of gut microbiota. By focusing on a proposed similar key role for T cells in Crohn's inflammation, we hypothesize that anti-flagellin antibodies that are highly shared by Crohn's patients, and characterize an aberrant B cell response, are potential markers for the presence T cell clonotypes that are reactive to the same gut...

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