Immune and Genetic Controls of Tissue Regeneration in Mice and Humans
Congressional District Code:
March 2018 -
FY 2021 Funding Amount:
Total Award Amount (all years):
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Abstract/Summary Cutaneous wounds create significant health problems for Veterans, including wartime trauma, diabetic foot ulcers, pressure ulcers, and pathological scar formation. We aim to devise novel methods to stimulate self- repair mechanisms and to promote scar-less wound healing/full tissue regeneration in humans. We use a combination of loss-of-function mouse genetics, parabiosis (where the circulatory systems of two mice are surgically connected), mass cytometry, flow cytometry, genomi...