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Project Number: | I01BX004160-01 |
| Title: | Mechanisms of Therapeutic Resistance in Prostate Cancer |
| Principal Investigator: | Yun Qiu |
| Location: | Baltimore, MD |
| Congressional District Code: | 7 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | April 2018 - March 2023 |
| FY 2023 Funding Amount: | $68,913 |
| Total Award Amount (all years): |
$1,410,366 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Background: Enhancer of zeste homolog 2 (EZH2) is a component of Polycomb Repressive Complex 2 (PRC2) and a key epigenetic regulator. EZH2 is overexpressed in metastatic prostate cancer (PCa), and its activity is critical for PCa progression and therapeutic resistance. Inhibition of EZH2 has become a promising cancer treatment option. Studies showed that agents depleting EZH2 protein had better antitumor efficacy than those only inhibiting its methyltransferase activity, suggesting that combinat... |