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Funded Project Details - FY2023

Project Number:

Title: Mechanisms of Therapeutic Resistance in Prostate Cancer
Principal Investigator:

Yun Qiu

Location: Baltimore, MD
Congressional District Code: 7
Research Service: Biomedical Laboratory R&D
Project Period: April 2018 - March 2023
FY 2023 Funding Amount: $68,913
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Background: Enhancer of zeste homolog 2 (EZH2) is a component of Polycomb Repressive Complex 2 (PRC2) and a key epigenetic regulator. EZH2 is overexpressed in metastatic prostate cancer (PCa), and its activity is critical for PCa progression and therapeutic resistance. Inhibition of EZH2 has become a promising cancer treatment option. Studies showed that agents depleting EZH2 protein had better antitumor efficacy than those only inhibiting its methyltransferase activity, suggesting that combinat...

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