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Project Number: | I01BX003674-01A2 |
| Title: | Mechanisms and Treatment of Kidney Fibrosis |
| Principal Investigator: | Michael Rauchman |
| Location: | St Louis, MO |
| Congressional District Code: | 1 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | January 2018 - March 2022 |
| FY 2021 Funding Amount: | $124,480 |
| Total Award Amount (all years): |
$697,991 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Project Summary Chronic kidney disease (CKD) affects ~15% of the U.S. population. Although a broad range of insults initiate kidney injury, fibrosis is a hallmark of all forms of progressive CKD. In spite of advances in delineating pathways that contribute to kidney fibrosis, there are no specific treatments for this serious disorder. TGF-β signaling is a central mediator of fibrosis in multiple tissues making it an attractive therapeutic target. However, because these cytokines have a wide ra... |