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Project Number: | I01CX000105-05A1 |
| Title: | Targeting F-box protein 048 in acute lung injury |
| Principal Investigator: | Toru Nyunoya |
| Location: | Pittsburgh, PA |
| Congressional District Code: | 14 |
| Research Service: | Clinical Science R&D |
| Project Period: | January 2018 - September 2022 |
| FY 2021 Funding Amount: | $65,000 |
| Total Award Amount (all years): |
$756,122 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Acute lung injury (ALI) is a devastating disorder among Veterans commonly occurring after sepsis or severe pneumonia. Two key manifestations of ALI are a fundamental inability to extract oxygen and inflammation, both of which may have a mitochondrial basis. Although ALI subjects have mitochondrial defects, the molecular mechanisms underlying their injury that disrupt oxygen consumption and trigger inflammation remain unclear. The mechanistic basis of this proposal resides on our discovery of a u... |