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Project Number: | I01BX003755-01A1 |
| Title: | Inhibiting pathological TDP-43 phosphorylation as a therapeutic strategy for ALS |
| Principal Investigator: | Brian C. Kraemer |
| Location: | Seattle, WA |
| Congressional District Code: | 9 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | April 2017 - March 2021 |
| FY 2021 Funding Amount: | $82,750 |
| Total Award Amount (all years): |
$988,915 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: TAR DNA-binding protein 43 kDa (TDP-43) is the major aggregating disease protein in amyotrophic lateral sclerosis (ALS). Over 90% of ALS cases exhibit pathological lesions containing detergent insoluble deposits of phosphorylated, truncated, and ubiquitinated TDP-43 protein. TDP-43 phosphorylated at S409/410 (pS409/410) is the most consistent, robust, and specific neuropathological feature of ALS suggesting a phosphorylated TDP-43 (pTDP) mediated cascade of neurotoxicity. Furthermore pTDP has be... |