MicroRNA Regulation of Phospholipid Homeostasis in Alzheimer's Disease Pathogenesis
Congressional District Code:
Biomedical Laboratory R&D
July 2017 -
FY 2021 Funding Amount:
Total Award Amount (all years):
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Background The ApoE4 genotype is the strongest genetic risk factor for developing AD. However, the mechanisms that underlie this link between ApoE4 genotype and SAD are not well understood. Objective/Hypothesis The objectives are to understand the molecular underpinnings of the association between ApoE4-specific changes in miRNA profile and ApoE4-induced brain phospholipid dysregulation which leads to ApoE4 increased susceptibility to develop SAD. Our recent findings demonstrate that ApoE protei...