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Project Number: | I01BX003380-01A2 |
| Title: | MicroRNA Regulation of Phospholipid Homeostasis in Alzheimer's Disease Pathogenesis |
| Principal Investigator: | Dongming Cai |
| Location: | Bronx, NY |
| Congressional District Code: | 13 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | July 2017 - December 2021 |
| FY 2021 Funding Amount: | $147,600 |
| Total Award Amount (all years): |
$883,692 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Background The ApoE4 genotype is the strongest genetic risk factor for developing AD. However, the mechanisms that underlie this link between ApoE4 genotype and SAD are not well understood. Objective/Hypothesis The objectives are to understand the molecular underpinnings of the association between ApoE4-specific changes in miRNA profile and ApoE4-induced brain phospholipid dysregulation which leads to ApoE4 increased susceptibility to develop SAD. Our recent findings demonstrate that ApoE protei... |