Office of Research & Development |
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Project Number: | I01BX003935-01 |
Title: | Understanding the Function of Tamm-Horsfall Protein in Acute Kidney Injury |
Principal Investigator: | Tarek Ashkar |
Location: | Indianapolis, IN |
Congressional District Code: | 7 |
Research Service: | Biomedical Laboratory R&D |
Project Period: | April 2017 - June 2021 |
FY 2021 Funding Amount: | $112,482 |
Total Award Amount (all years): |
$781,968 |
Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Acute kidney injury (AKI) is a major determinant of mortality and morbidity in hospitalized veterans. Understanding the pathophysiology of AKI is essential for the development of therapy. This application proposes to study the role of Tamm-Horsfall protein (THP) in AKI. This protein is expressed exclusively in the kidney by cells of the thick ascending limbs (TAL) of Henle. In the last funding cycle, we uncovered a key role of THP in mediating a protective tubular cross-talk in AKI. We showed th... |