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Project Number: | I01BX001923-05 |
| Title: | Role of Cholesterol in Age-related Decline in Steroidogenesis |
| Principal Investigator: | Salman Azhar |
| Location: | Palo Alto, CA |
| Congressional District Code: | 14 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | October 2016 - March 2021 |
| FY 2021 Funding Amount: | $0 |
| Total Award Amount (all years): |
$752,277 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Numerous cross-sectional and longitudinal studies have established that circulating levels of testosterone decline with age in men, and this decline has been associated with parallel age-related metabolic and pathophysiological changes such as increased fat mass, cardiovascular risk, and incidence of frailty, depression, osteopenia, osteoporosis, insulin resistance and type 2 diabetes and decreased muscle/bone mass, and sexual function. Likewise, aging of the human ovary also results in a gradua... |