Office of Research & Development |
  |
Talk to the Veterans Crisis Line now
An official website of the United States government
Project Number: | IK2CX001471-01A1 |
| Title: | Role of IL-6 and IL-1b in immune dysfunction during aging, HIV, and HCV infection |
| Principal Investigator: | Carey Shive |
| Location: | Cleveland, OH |
| Congressional District Code: | 11 |
| Research Service: | Clinical Science R&D |
| Project Period: | January 2017 - December 2021 |
| FY 2021 Funding Amount: | $202,612 |
| Total Award Amount (all years): |
$967,979 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Chronic systemic inflammation is associated with immune dysfunction and morbidities in the elderly, treated HIV infection, and HCV infection. We propose that circulating inflammatory proteins drive immune exhaustion and senescence and contribute to the immune dysfunction seen in these patient groups. Nearly 4 million Americans are infected with Hepatitis C Virus (HCV) and the mean age of US veterans infected with HCV is nearing 65 years. Although the new IFN-free direct-acting antiviral therapy... |