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Project Number: | I01BX003262-01A2 |
| Title: | Proximal Differentiation Therapy for K-Ras-Induced Lung Adenocarcinoma |
| Principal Investigator: | Mark Onaitis |
| Location: | San Diego, CA |
| Congressional District Code: | 52 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | October 2017 - September 2021 |
| FY 2021 Funding Amount: | $165,000 |
| Total Award Amount (all years): |
$645,000 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: ABSTRACT Individualized therapeutics for K-RAS mutant lung adenocarcinoma are nonexistent. Recently, we have described a unique interaction between activated K-Ras and the Type II cell that explains the unique ability of the Type II cell to proliferate in response to K-Ras activation. The absence of the transcription factor Sox2 allows Notch to be upregulated when K-Ras is activated. In addition, K-Ras is able to induce a transcriptional program that dedifferentiates distal lung epithelial cells... |