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Project Number: | I01BX001108-05 |
| Title: | Mechanisms of ER Stress and Neurodegeneration in Amyotrophic Lateral Sclerosis |
| Principal Investigator: | Eric J. Huang |
| Location: | San Francisco, CA |
| Congressional District Code: | 12 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | July 2016 - December 2020 |
| FY 2021 Funding Amount: | $0 |
| Total Award Amount (all years): |
$581,250 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: DESCRIPTION (provided by applicant): Amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease, is an adult-onset neurodegenerative disease that affects upper and lower motor neurons. The key clinical features in ALS patients include muscle wasting, and progressive loss of spinal motor neurons and upper motor neurons and their axons in the lateral columns of the spinal cord. The past 10 years have witnessed a tremendous expansion in the molecular mechanisms of this devastating dis... |