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Project Number: | I01BX001108-09A1 |
| Title: | Mechanisms of ER Stress and Neurodegeneration in Amyotrophic Lateral Sclerosis |
| Principal Investigator: | Eric J. Huang |
| Location: | San Francisco, CA |
| Congressional District Code: | 12 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | April 2021 - March 2025 |
| FY 2021 Funding Amount: | $78,400 |
| Total Award Amount (all years): |
$710,000 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Neurodegenerative diseases are characterized by accumulation of misfolded proteins in disease-specific neural circuits, which disrupts normal neuronal functions, including axonal transport, mitochondrial bioenergetics, gene expression, and synaptic connectivity. In addition, there is compelling evidence that neuroinflammation can also initiate and/or facilitate disease progression. These results support an interconnected mechanism, in which protein misfolding and neuroinflammation synergisticall... |