The immunomodulatory function of Tamm-Horsfall protein in acute kidney injury
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Biomedical Laboratory R&D
July 2021 -
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View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt:
Acute kidney injury (AKI) is a major determinant of mortality and morbidity in hospitalized veterans. Understanding the pathophysiology of AKI is essential for the development of therapy. This application proposes to study the role of Tamm-Horsfall protein (THP) in AKI. This protein is expressed exclusively in the kidney by cells of the thick ascending limbs (TAL) of Henle. In the last funding cycle, we uncovered a key role of THP in regulating neutrophil infiltration in AKI. The current proposa...