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Funded Project Details - FY2021




Project Number:

I01RX002274-05
Title: Tissue Engineered Total Disc Replacement in a Large Animal Model
Principal Investigator:

Harvey Smith

Location: Philadelphia, PA
Congressional District Code: 3
Research Service: Rehabilitation R&D
Project Period: April 2021 - March 2025
FY 2021 Funding Amount: $50,000
Total Award Amount
(all years):
$1,272,000
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Low back pain, which is most commonly caused by intervertebral disc degeneration, is the most common source of chronic pain in veterans. Current clinical treatments for disc degeneration, including spinal fusion, are limited in that they do not restore healthy disc structure or function. To overcome this limitation, our group has developed a whole, tissue engineered endplate-modified disc-like angle ply structure (eDAPS) composed of engineered annulus fibrosus, nucleus pulposus and endplate regi...



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