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Funded Project Details - FY2021

Project Number:

Title: Cholangiocyte-Derived Endothelin Signaling Mediates Biliary Injury and Liver Fibrosis
Principal Investigator:

Lindsey Kennedy

Location: Indianapolis, IN
Congressional District Code: 7
Research Service: Biomedical Laboratory R&D
Project Period: January 2021 - December 2024
FY 2021 Funding Amount: $143,953
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


The main goal of this application is to clarify the signaling mechanisms mediating biliary senescence and angiogenesis during primary sclerosing cholangitis (PSC). It is known that (i) endothelin (ET)-1 signaling is enhanced in the bile duct ligation (BDL) model of obstructive cholestasis, (ii) it is primarily upregulated in cholangiocytes and (iii) enhances liver fibrosis via hepatic stellate cell (HSC) activation. Outside of the liver, ET-1 is a potent vasoconstrictor and enhances transforming...

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