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Funded Project Details - FY2021

Project Number:

Title: Role of Cyr61/CCN1 in Pancreatic Cancer Progression and Therapy
Principal Investigator:

Snigdha Banerjee

Location: Kansas City, MO
Congressional District Code: 5
Research Service: Biomedical Laboratory R&D
Project Period: October 2020 - September 2024
FY 2021 Funding Amount: $341,734
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Pancreatic ductal adenocarcinoma (PDAC) remains one of the leading sources of cancer mortality worldwide, including US Veterans. An initial response to chemotherapy, such as Gemcitabine (GEM) is often followed by emergent resistance reflecting an urgent need for targeted therapies. Our studies have found that CYR61 is a druggable PDAC driver, and it can be suppressed by Zoledronic acid (ZA) under tissue culture conditions. Regrettably, the weak availability in the target tissue limits the therap...

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