Toward Closed-Loop Control of Homeostatic Blood Pressure Following Spinal Cord Injury
Congressional District Code:
December 2020 -
FY 2021 Funding Amount:
Total Award Amount (all years):
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt:
Rationale: Approximately 42,000 Veterans have a spinal cord injury (SCI). For the 65% of these individuals with an SCI above thoracic (T) spinal level 6, both hypo- and hypertension are common comorbidities. SCI above T6 increases the risk for autonomic dysreflexia (AD) because the central descending control over the greater splanchnic nerves (GSNs) is lost, and with it the ability to control the abdominal splanchnic vasculature. Uncontrolled hyperreflexia in the GSNs can evolve to AD-induced hy...