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Funded Project Details - FY2021

Project Number:

Title: Toward Closed-Loop Control of Homeostatic Blood Pressure Following Spinal Cord Injury
Principal Investigator:

Matthew Schiefer

Location: Gainesville, FL
Congressional District Code: 3
Research Service: Rehabilitation R&D
Project Period: December 2020 - November 2022
FY 2021 Funding Amount: $56,222
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Rationale: Approximately 42,000 Veterans have a spinal cord injury (SCI). For the 65% of these individuals with an SCI above thoracic (T) spinal level 6, both hypo- and hypertension are common comorbidities. SCI above T6 increases the risk for autonomic dysreflexia (AD) because the central descending control over the greater splanchnic nerves (GSNs) is lost, and with it the ability to control the abdominal splanchnic vasculature. Uncontrolled hyperreflexia in the GSNs can evolve to AD-induced hy...

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