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Funded Project Details - FY2021

Project Number:

Title: Using FHF2 to Adjust the Gain on Pain
Principal Investigator:

Philip Effraim

Location: West Haven, CT
Congressional District Code: 3
Research Service: Rehabilitation R&D
Project Period: September 2020 - August 2022
FY 2021 Funding Amount: $269,810
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


The prevalence of chronic pain is higher in Veterans compared to the civilian population. Current treatments rely heavily on the use of opioids. The lack of adequate alternative treatments has led to overuse of opioids in the management of pain. These facts highlight the urgent need for alternative pain treatment options. The work outlined in this proposal will focus on voltage-gated sodium channel Nav1.7, an important component in human pain signaling. Single amino acid mutations in Nav1.7 caus...

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