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Funded Project Details - FY2021




Project Number:

I01CX002028-01A1
Title: Leucoselect Phytosome for Neoadjuvant Treatment of Early Stage Lung Cancer
Principal Investigator:

Jenny T. Mao

Location: Albuquerque, NM
Congressional District Code: 1
Research Service: Clinical Science R&D
Project Period: October 2020 - September 2025
FY 2021 Funding Amount: $110,000
Total Award Amount
(all years):
$1,400,000
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Ample preclinical data suggests that grape seed procyanidin extract (GSE) possesses multi-faceted anticancer properties. GSE has been shown to favorably modulate carcinogenic mechanisms, including 1) major eicosanoids pathways, such as inhibitions of cyclocoxygenase (COX)-2/prostaglandin (PG)E2, induction of prostacyclin synthase (PTGIS)/PGI2 and increase production of 15(S)-hydroxy-eicosatetraenoic acid (15-HETE); 2) downregulation of oncomirs microRNA (miR)-19a, -19b and up-regulations of thei...



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