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Project Number: | I01CX001895-01A2 |
| Title: | Epigenetic Regulation of Differentially Expressed Genes in Cutaneous T Cell Lymphoma |
| Principal Investigator: | Henry K Wong |
| Location: | Little Rock, AR |
| Congressional District Code: | 2 |
| Research Service: | Clinical Science R&D |
| Project Period: | July 2021 - June 2025 |
| FY 2021 Funding Amount: | $87,197 |
| Total Award Amount (all years): |
$655,551 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Genomic instability and dysregulated epigenetic control are now both recognized as hallmarks of cancer, although the mechanisms responsible are poorly understood. Both lead to abnormal gene expression, and gains and losses of function that can promote oncogenesis. Tumor suppressor genes are often repressed by hypermethylation of CpG sites. Cancer genomes are also frequently globally hypomethylated. Hypomethylation of gene-regulatory elements, such as transcription factor binding sites and enhanc... |