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Funded Project Details - FY2021

Project Number:

Title: Cellular Heterogeneity and Aging in MDS and AML
Principal Investigator:

Austin Gillen

Location: Denver, CO
Congressional District Code: 6
Research Service: Biomedical Laboratory R&D
Project Period: July 2021 - June 2026
FY 2021 Funding Amount: $80,228
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


The goal of this application is to increase the efficacy of existing treatments for myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) by identifying and characterizing RNA processing phenotypes that predict age-related disease progression and drug resistance. Current therapies for both of these devastating diseases are effective in only a small number of patients and predicting responses remains challenging. Improving response rates represents a substantial unmet need for Veterans....

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