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Project Number: | I01BX005184-01 |
| Title: | Mitochondria Functions Modified by Sulfotransferase 1C2 |
| Principal Investigator: | Robert L. Bacallao |
| Location: | Indianapolis, IN |
| Congressional District Code: | 7 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | July 2020 - June 2024 |
| FY 2021 Funding Amount: | $156,800 |
| Total Award Amount (all years): |
$710,000 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Acute kidney injury (AKI) is the most common renal disease requiring hospitalization and is associated with significant mortality. There remains no reliable treatment modality for acute kidney injury. In the setting of ischemia or hypoxic injury, early alterations in mitochondrial structure impair cellular energetics, activate cell death pathways, increase oxygen free radical generation and may influence renal hemodynamics. Different models of naturally or experimentally induced resistance to is... |