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Funded Project Details - FY2023

Project Number:

Title: Targeting metabolism in AML
Principal Investigator:

David Wald

Location: Cleveland, OH
Congressional District Code: 11
Research Service: Biomedical Laboratory R&D
Project Period: October 2020 - September 2024
FY 2023 Funding Amount: $165,000
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Acute myeloid leukemia (AML) is the most common type of acute leukemia affecting adults, but unfortunately there has been no change in standard therapy for most patients in over 40 years. Traditional chemotherapeutics exhibit poor efficacy in patients over the age of 56, with a median survival of less than one year and only 20% surviving two years. The development of novel therapies for AML is urgently needed. We previously identified a plant derived alkaloid as a promising agent that impaired t...

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