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Funded Project Details - FY2021

Project Number:

Title: Ischemia-induced injury to neuronal processes: role of cofilin-actin rod formation
Principal Investigator:

Raymond A. Swanson

Location: San Francisco, CA
Congressional District Code: 12
Research Service: Biomedical Laboratory R&D
Project Period: July 2020 - June 2024
FY 2021 Funding Amount: $196,968
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Disability caused by ischemic stroke results not only from neuronal death, but also from injury to axons and dendrites of surviving neurons. The mechanisms by which ischemia causes injury to these neuronal processes are not well understood, and have not been well-explored as a therapeutic target. Cofilin-actin rods are 1:1 linear aggregates of cofilin-1 and actin that form in neuronal processes under conditions of ATP depletion or oxidant stress. These rods cause degeneration of the neuronal pro...

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