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Funded Project Details - FY2021

Project Number:

Title: Mechanism of Integrative Metabolic Regulation by Iron and Hypoxia
Principal Investigator:

Donald A. McClain

Location: Salisbury, NC
Congressional District Code: 13
Research Service: Biomedical Laboratory R&D
Project Period: October 2020 - September 2024
FY 2021 Funding Amount: $154,868
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


PROJECT SUMMARY Insulin resistance, excess hepatic glucose production, and impaired insulin secretion are the hallmarks of type 2 diabetes mellitus (T2DM), and tissue iron levels significantly affect all three. In mice and humans, we have shown that high iron impairs insulin secretion and down regulates leptin and adiponectin. Our preliminary data show further that these effects of iron are fuel-dependent, with much of this difference based on higher iron levels supporting higher levels of fat...

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