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Project Number: | I01RX001475-06A1 |
| Title: | Autonomic Regulation of the Immunological Response to Limb Injury |
| Principal Investigator: | David J. Clark |
| Location: | Palo Alto, CA |
| Congressional District Code: | 18 |
| Research Service: | Rehabilitation R&D |
| Project Period: | August 2020 - July 2025 |
| FY 2021 Funding Amount: | $124,000 |
| Total Award Amount (all years): |
$1,184,704 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: A major recent advancement for the field of pain research is the recognition of immune system dysregulation as a contributor to the most serious adverse outcomes from injury. Both autoinflammation involving mediators of inflammation and autoimmunity involving autoantibodies have been identified in patients with chronic pain and disability after limb trauma. Taking advantage of these advancements, the overarching goal of the proposed research is to identify novel approaches to controlling immune... |